Since tolerances and exemptions that are established on the basis of a petition under section 408(d) of FFDCA, such as the tolerance in this final rule, do not require the issuance of a proposed rule, the requirements of the Regulatory Flexibility Act (RFA) (5 U.S.C. The trinexapac-ethyl changes the size of the corn p lants, enabling new spatial arrangements. It does not represent any guarantee of the properties of the product. Counts are subject to sampling, reprocessing and revision (up or down) throughout the day. LOAEL = 360 mg/kg/day, based on a decrease in mean number of fetuses/litter and an increase in post-implantation loss. Refer for medical attention . on NARA's archives.gov. To summarize this first year of work with plant growth regulators, we found a trend for one to two inch reductions in plant height when Palisade or Palisade plus Tilt were applied, but this only translated to increased grain yield at one site. search more_vert. Trinexapac Ethyl improves rich color and root mass development. These can be useful informational resource until the Administrative Committee of the Federal NW., Washington, DC 20460-0001; telephone number: (703) 347-8072; email address: benbow.bethany@epa.gov. Wheat lodging is not generally a widespread problem in Oklahoma, but it does occur. The Public Inspection page may also Room temperature in continental US; may vary elsewhere. However, to the best of our knowledge, TE has not been used to study the requirement of GAs in onset of germination. Acting as a growth inhibitor, this chemical can be used to prevent lodging in crops. This regulation establishes tolerances for residues of trinexapac-ethyl in or on multiple commodities which are identified and discussed later in this document. EPA has established a docket for this action under docket identification (ID) number EPA-HQ-OPP-2010-0524. Results of the acute neurotoxicity study show no indications of neurotoxicy at the highest dose. Germination studies were conducted using seeds of artichoke thistle and common teasel under a range of TE . ), do not apply. To summarize our work, we found a trend for one to two inch reductions in plant height when Palisade or Palisade plus Tilt were applied, but this did not consistently translate to increased grain yield. Counts are subject to sampling, reprocessing and revision (up or down) throughout the day. This repetition of headings to form internal navigation links If you are worried about bronzing, tank mix a product that contains manganese rather than iron. Suppliers of Trinexapac-ethyl Download SDS (editable Word file) and other types SDS | Offered by XiXisys.com SAFETY DATA SHEETS According to the UN GHS revision 8 Version: 1.0 Creation Date: July 15, 2019 Revision Date: July 15, 2019 SECTION 1: Identification 1.1 GHS Product identifier Product name Clethodim. 2023 United States Golf Association. documents in the last year, 522 Process Trigger: First Food Use Registration Review Case: TRINEXAPAC-ETHYL , Case #7228: Substance Information . Those assessments rely on tolerance-level residues, 2019 default processing factors, and an assumption of 100% crop treated (PCT). Contact us today for pricing & size information. Once a pesticide's toxicological profile is determined, EPA identifies toxicological points of departure (POD) and levels of concern (LOC) to use in evaluating the risk posed by human exposure to the pesticide. Mix in manganese. Therefore, based on the risk assessments and information described above, EPA concludes there is a reasonable certainty that no harm will result to the general population or to infants and children from aggregate exposure to trinexapac-ethyl residues. Revising the existing entries in the table for Sugarcane, cane and Sugarcane, molasses. Trinexapac-ethyl 25%ec, 250g/l ec from Chinese Other supplier - Meorient Import & Export Co.LTD on tradechina.com . hVk0W=}Xd(&[Xa+ KLbH{lww%K/c?t/I_"E&`Rd)ZS1DI3kxJ _vOU\,P 3ee2'mF3[A6Q`'^?cOvnLT`#L~[nrM-u=l >W==VnoM}?6vQ7K~W7MWIfK{ _uxP!uL [?]K@_PY`,dOcrT+y0e[zj~"PNsZCP}^SPL##P>3@Z. documents in the last year, 861 Neither comment was accompanied by any substantiation nor data supporting a conclusion that the tolerances being established in this action do not meet the FFDCA safety standard. search. Avoid contact with skin and eyes. Therefore, EPA is increasing tolerances for residues of trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate, including Start Printed Page 70064its metabolites and degradates, in or on sugarcane, cane at 1.5 ppm, and sugarcane, molasses at 5 ppm. the material on FederalRegister.gov is accurately displayed, consistent with There are clear NOAELs/LOAELs for this effect; in which the NOAEL dose is 10-fold lower than the LOAEL dose at which neuropathology is observed, and is therefore sufficiently protective. Emergency exemptions may be requested by a state or federal agency. This feature is not available for this document. Trinexapac-ethyl Chemical Structures GB RN 1422 Trade Name GOVERNOR G Label Indication Conventional Chemical CB RN 748461 Country USA Company THE ANDERSONS, INC. CAS RN 143294-89-7; 104273-73-6 Product Type Formulation IUPAC Name 4- [cyclopropyl (hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid Compound Indication PLANT GROWTH REGULATOR Aggregate cancer risk for U.S. population. documents in the last year, 822 Short- and intermediate-term risk. Experiments were conducted in New Jersey to investigate efficacy and absorption of bispyribac-sodium applied with trinexapac-ethyl for annual bluegrass control and turfgrass tolerance. tradeKorea is a online B2B trade website offers you matching services to connect buyers and suppliers. For the purposes of this tolerance action, therefore, EPA has assumed that trinexapac-ethyl does not have a common mechanism of toxicity with other substances. Lose the iron and calcium. 346a(d)(3), announcing the filing of two pesticide petitions (PP 0F7719 and 0F7720) by Syngenta Crop Protection, Inc., P.O. When following these steps, you will likely find higher than usual suppression, so lower application rates of actual product should be used. Agricultural Chemical. To ensure proper receipt by EPA, you must identify docket ID number EPA-HQ-OPP-2010-0524 in the subject line on the first page of your submission. Acting Director, Registration Division, Office of Pesticide Programs. Section 408(b)(2)(C) of FFDCA requires EPA to give special consideration to exposure of infants and children to the pesticide chemical residue in establishing a tolerance and to ensure that there is a reasonable certainty that no harm will result to infants and children from aggregate exposure to the pesticide chemical residue. Because this final rule has been exempted from review under Executive Order 12866, this final rule is not subject to Executive Order 13211, entitled Actions Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April 23, 1997). Trinexapac-ethyl 4-()-3,5-4-(Cyclopropyl-alpha-hydroxymethylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester C13H16O5 252.27 FW252.27 36.0mp36.0>270bp>270pKa: 4.71.6mPa(20) 2.16mpa(25)(20g/L)2.8(pH 4.9)10.2(pH 5.5)21.1(pH 8.2)5% This final rule directly regulates growers, food processors, food handlers, and food retailers, not States or tribes, nor does this action alter the relationships or distribution of power and responsibilities established by Congress in the preemption provisions of section 408(n)(4) of FFDCA. documents in the last year, 1479 Substance Name: Trinexapac-ethyl [ISO] RN: 95266-40-3 UNII: Q89W563T9J InChIKey: RVKCCVTVZORVGD-QXMHVHEDSA-N. In addition, EPA periodically reevaluates pesticides to ensure their safety in light of new scientific and regulatory information. clothing Rinse skin immediately with plenty of water for 15-20 minutes. documents in the last year, by the Federal Highway Administration on NARA's archives.gov. 804(2). In addition to filing an objection or hearing request with the Hearing Clerk as described in 40 CFR part 178, please submit a copy of the filing that does not contain any CBI for inclusion in the public docket. Based on these risk assessments, EPA concludes that there is a reasonable certainty that no harm will result to the general population, or to infants and children from aggregate exposure to trinexapac-ethyl residues. Occupational More information and documentation can be found in our Dietary exposure from food and feed uses. rendition of the daily Federal Register on FederalRegister.gov does not The toxicology database for trinexapac-ethyl is largely complete, with the exception of a subchronic neurotoxicity study, which is a new data requirement under 40 CFR part 158 for registration of a pesticide (food and non-food uses OPPTS 870.6200b). developer tools pages. 02/28/2023, 267 document.write(" Prin<\/span>t<\/a> <\/a>\u00A0|") Although listed in the index, some information is not publicly available, e.g., Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. See what the USGA is doing to ensure a strong future for the game. 1503 & 1507. Many of the proposed tolerances are different from the tolerances being set by EPA. In the Federal Register of March 3, 2020 (85 FR 12454) (FRL-10005-58), EPA issued a document pursuant to FFDCA section 408(d)(3), 21 U.S.C. Before making a final registration decision on trinexapac-ethyl and MODDUS, Health Canada's PMRA will consider any comments received from the public in response to PRD2020-13. Uncertainty/safety factors (U/SF) are used in conjunction with the POD to calculate a safe exposure levelgenerally referred to as a population-adjusted dose (PAD) or a reference dose (RfD)and a safe margin of exposure (MOE). documents in the last year, 87 Trinexapac-ethyl is a plant growth regulator that inhibits the biosynthesis of gibberellin. Trinexapac-ethyl Chemical Structures GB RN 1422 Trade Name LPI.A004 Label Indication Conventional Chemical CB RN 756428 Country USA Company LOVELAND PRODUCTS, INC. CAS RN 143294-89-7; 104273-73-6 Product Type Formulation IUPAC Name 4- [cyclopropyl (hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid Compound Indication Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent . For complete information about, and access to, our official publications The acute toxicity of trinexapac-ethyl is low via the oral, eye, dermal, or inhalation routes of exposure, and it is not a dermal sensitizer. Do NOT wash away into sewer. Root lodging occurs when the anchorage system of a top-heavy wheat plant is weakened due to moist soil and wind provides sufficient force to overcome the rotational stiffness of the root/soil complex. Registration provide legal notice to the public or judicial notice to the courts. Based upon review of the data supporting the petition, EPA is modifying the tolerance expression and the tolerance for sugarcane, molasses at a different level than petitioned-for. The President of the United States issues other types of documents, including but not limited to; memoranda, notices, determinations, letters, messages, and orders. documents in the last year, 1479 Table 1Summary of Toxicological Doses and Endpoints for Trinexapac-ethyl for Use in Human Health Risk Assessment. Lodging occurs due to a variety of factors, and as shown in the figure below, the timing of lodging will determine the final impact on grain yield. Use non-sparking tools. by the Patent and Trademark Office These markup elements allow the user to see how the document follows the Rinse skin with plenty of water or shower. The following five field observations are strategies that may increase the effectiveness of trinexapac-ethyl when applying it for bermudagrass growth suppression: Use a low carrier volume. documents in the last year, 940 Register documents. When low carrier volumes are coupled with finer spray particles, it seems that lower product rates can be used because foliar coverage is maximized. 2020-23040 Filed 11-3-20; 8:45 am], updated on 4:15 PM on Tuesday, February 28, 2023, updated on 8:45 AM on Tuesday, February 28, 2023, 104 documents In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. 601 et seq.) documents in the last year, 287 to TE has not been widely investigated.In four field experiments, different rates . regulatory information on FederalRegister.gov with the objective of - Double-bond stereo. Application of Palisade or Palisade plus Tilt increased grain yield at Chickasha and had no effect on grain yield at Stillwater or Perkins in 2013. (b) Section 18 emergency exemptions. . All objections and requests for a hearing must be in writing, and must be received by the Hearing Clerk on or before January 4, 2021. Trinexapac-ethyl (TE) is well-known as an anti-gibberellin plant growth regulator [1] . The United States is not able to harmonize its sugarcane tolerance with the Codex MRL; based on the reduction of the preharvest interval (PHI) from 28 to 14 days on sugarcane, the field trial data indicate that use in accordance with the label results in residues may exceed tolerances if they were harmonized with Codex. Therefore, for the reasons stated in the preamble, EPA amends 40 CFR chapter I as follows: 1. In evaluating dietary exposure to trinexapac-ethyl, EPA considered exposure under the petitioned-for tolerances. documents in the last year, by the Fish and Wildlife Service Trinexapac-ethyl is a synthetic plant growth regulator that is derived from cyclohexanecarboxylate. Addresses for mail and hand delivery of objections and hearing requests are provided in 40 CFR 178.25(b). Residues were extracted from wheat with acetonitrile in aqueous phosphate buffer (pH 7) overnight. This site displays a prototype of a Web 2.0 version of the daily EPA's exposure assessments have been updated to include the additional exposure from the increased tolerance of trinexapac-ethyl from use in or on sugarcane, cane and sugarcane, molasses. Trinexapac-ethyl is a plant growth regulator that inhibits the formation of gibberellic acid and is used as an anti-lodging agent. Many Oklahoma wheat farmers battled lodged wheat in 2013 and are looking to plant growth regulators to help reduce lodging in 2014. Sweep spilled substance into covered sealable containers. Personal protection: P2 filter respirator for harmful particles. Chemical Name: Cyclohexanecarboxylic acid, 4-(cyclopropylhydroxymethylene)-3,5-dioxo-, ethyl ester: Announcements. NO open flames. 801 et seq., generally provides that before a rule may take effect, the agency promulgating the rule must submit a rule report to each House of the Congress and to the Comptroller General of the United States. Name: Trinexapac-ethyl: Trinexapac-ethyl; 4- (Cyclopropyl-alpha-hydroxymethylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester; Ethyl 4-cyclopropyl (hydroxy)methylene-3,5-dioxocyclohexanecarboxylate These markup elements allow the user to see how the document follows the Document page views are updated periodically throughout the day and are cumulative counts for this document. include documents scheduled for later issues, at the request Ensure adequate ventilation. 02/28/2023, 267 There are no tolerances currently established for trinexapac-ethyl. documents in the last year, 83 This table of contents is a navigational tool, processed from the Register, and does not replace the official print version or the official 272 note). This repetition of headings to form internal navigation links from 47 agencies. Furthermore, the lesions remained confined to the supporting cells in the central nervous system (CNS) and did not progress to more advanced or more extensive damage of the nervous tissue. Use water spray, powder, foam, carbon dioxide. Trinexapac-ethyl, TMS derivative. ABSTRACT. Therefore, short-term dermal post-application exposures and risks were also assessed for trinexapac-ethyl. Registration Review. Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. How doesTrinexapac-ethyl work? Federal Register issue. MODDUS contains trinexapac-ethyl for use as a growth regulator in wheat, barley, oats, rye, triticale, durum wheat and ryegrass seed crops. Be sure to consider the method of trinexapac-ethyl application when trying to maximize effectiveness. The global key manufacturers of Trinexapac-ethyl include Syngenta, Nuturf, ADAMA, Nanjing Gaozheng Agricultural Chemical and Shanghai Agrogreat Industrial, etc. Although there is evidence of susceptibility in the rat and rabbit developmental studies and in the rat reproduction study, EPA's concern for these effects is low, and there are no residual uncertainties since the effects only occurred at the highest doses tested (360-1,200 mg/kg/day), for each study, and there were clearly identified NOAELs (60-593 mg/kg/day) for each fetal/offspring effect. documents in the last year, 1408 Information on this page: Gas Chromatography; headings within the legal text of Federal Register documents. Federal Register issue. This final rule does not contain any information collections subject to OMB approval under the Paperwork Reduction Act (PRA), 44 U.S.C. Last updated on July 5, 2022 02/28/2023, 828 daily Federal Register on FederalRegister.gov will remain an unofficial Conversely, when larger carrier volumes are used, the coarser spray droplets result in reduced foliar coverage. headings within the legal text of Federal Register documents. Bispyribac-sodium selectively controls annual bluegrass in cool-season turf but efficacy may be influenced by management practices, such as plant growth regulator use. Because EPA's level of concern for trinexapac-ethyl is a MOE of 100 or below, these MOEs are not of concern. While application of Palisade resulted in numeric reductions in plant height at Chickasha and Stillwater, differences among treatments were not statistically significant. You must file your objection or request a hearing on this regulation in accordance with the instructions provided in 40 CFR part 178. As such, the Agency has determined that this action will not have a substantial direct effect on States or tribal governments, on the relationship between the national government and the States or tribal governments, or on the distribution of power and responsibilities among the various levels of government or between the Federal Government and Indian tribes. To ensure proper receipt by EPA, you must identify docket ID number EPA-HQ-OPP-2020-0046 in the subject line on the first page of your submission. [Reserved], (c) Tolerances with regional registrations. The method may be requested from: Chief, Analytical Chemistry Branch, Environmental Science Center, 701 Mapes Rd., Ft. Meade, MD 20755-5350; telephone number: (410) 305-2905; email address: residuemethods@epa.gov. document.write(" Hide\u00A0index<\/span><\/a>\u00A0|") Approval under the petitioned-for tolerances 's archives.gov are different from the tolerances being set by.. 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Public or judicial notice to the Public Inspection page may also Room temperature in continental US may... Powder, foam, carbon dioxide mg/kg/day, based on a decrease in mean number fetuses/litter. Other supplier - Meorient Import & amp ; Export Co.LTD on tradechina.com USGA is doing ensure. 100 % crop treated ( PCT ): Announcements were also assessed for trinexapac-ethyl assumption 100! From food and feed uses turfgrass tolerance the existing entries in the last year, 87 trinexapac-ethyl a! Respirator for harmful particles tradekorea is a online B2B trade website offers you matching to! & amp ; Export Co.LTD on tradechina.com, Nuturf, ADAMA, Nanjing Gaozheng Agricultural chemical and Agrogreat. Registration provide legal notice to the Public or judicial notice to the of!, differences among treatments were not statistically significant in addition, EPA periodically reevaluates pesticides to ensure safety! 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Sugarcane, cane and Sugarcane, molasses approval under the Paperwork Reduction Act ( PRA ), 44.! Rates of actual product should be used to prevent lodging in crops Nuturf, ADAMA, Nanjing Gaozheng Agricultural and... Of the proposed tolerances are different from the tolerances being set by EPA in or multiple! Widely investigated.In four field experiments, different rates show no indications of neurotoxicy the. Repetition of headings to form internal navigation links from 47 agencies repetition of headings to form navigation. Tolerances are different from the tolerances being set by EPA Palisade resulted in reductions! Were conducted using seeds of artichoke thistle and common teasel under a range of TE in plant height at and! Human Health risk Assessment trinexapac-ethyl 25 % ec, 250g/l ec from Chinese Other supplier Meorient! Repetition of headings to form internal navigation links from 47 agencies manufacturers of trinexapac-ethyl application when trying maximize! 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